To remediate a potential NPM Dependency Confusion, follow these steps. First, conduct an audit using tools like npm audit or vulnerability scanners to identify vulnerable packages. Next, pin dependencies to specific versions in your project's configuration files (e.g., package.json, yarn.lock) to ensure exact versions are installed. Verify package sources by configuring the `.npmrc` file to use trusted registries, avoiding untrusted or unknown sources. Remove or replace suspicious or unauthorized packages found during the audit, using tools like npm ls to check for conflicting sources. Finally, keep dependencies up to date by regularly reviewing and updating them using package manager commands (npm update, yarn upgrade), ensuring you have the latest versions and security patches.